Chlorhexidine baths in ICU don’t prevent infections in large trial

http://ift.tt/eA8V8J Throwing the Baby out with the (Chlorhexidine) Bathwater? New Data on Disinfectant Baths By Lekshmi Santhosh, MD As a critical care community, we’ve been forever searching for a magic bullet to eradicate healthcare-acquired infections. So when the pair of 2013 NEJM trials on daily chlorhexidine bathing showed statistically significant reductions on the incidence of …

The HELP Trial, 2014

http://ift.tt/eA8V8J Author: Ged Dalgleish Reviewer: Chris Nickson Journal Club 015 Rahimi RS, Singal AG, Cuthbert JA, Rockey DC. Lactulose vs polyethylene glycol 3350 – electrolyte solution for treatment of overt hepatic encephalopathy: the HELP randomized clinical trial. JAMA Intern Med. 2014 Nov;174(11):1727-33. doi: 10.1001/jamainternmed.2014.4746. PubMed PMID: 25243839. THE QUESTION Does catharsis of the gut using polyethylene …

PROPPR: Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma. The PROPPR Randomized Clinical Trial

http://ift.tt/1FG3jzU PROPPR Study Group*, JAMA. 2015;313(5):471-482 Clinical Question In patients with severe trauma and predicted to require massive transfusion, does the use of a transfusion protocol using a 1:1:1 ratio of plasma to platelets to red blood cells (RBCs) compared to 1:1:2 improve mortality? Design Randomised-controlled trial Treating clinicians non-blinded Allocation concealment maintained through use …